Publications

Publication Overview

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Flat clathrin lattices are dynamic actin-controlled hubs for clathrin-mediated endocytosis and signalling of specific receptors.pdf-icon

Leyton-Puig D, Isogai T, Argenzio E, van den Broek B, Klarenbeek J, Janssen H, Jalink K, Innocenti M.
Nat Commun. 2017 Jul 13;8:16068. doi: 10.1038/ncomms16068.

Schwann cells are activated by ATP released from neurons in an in vitro cellular model of Miller Fisher syndrome.

Rodella U, Negro S, Scorzeto M, Bergamin E, Jalink K, Montecucco C, Yuki N, Rigoni M.
Dis Model Mech. 2017 Jan 6. pii: dmm.027870. doi: 10.1242/dmm.027870.

Glycerophosphodiesterase GDE2 Promotes Neuroblastoma Differentiation through Glypican Release and Is a Marker of Clinical Outcome.

Matas-Rico E, van Veen M, Leyton-Puig D, van den Berg J, Koster J, Kedziora KM, Molenaar B, Weerts MJ, de Rink I, Medema RH, Giepmans BN, Perrakis A, Jalink K, Versteeg R, Moolenaar WH.
Cancer Cell. 2016 Oct 10;30(4):548-562. doi: 10.1016/j.ccell.2016.08.016.

Hypersensitivity to DNA damage in antephase as a safeguard for genome stability.

Feringa FM, Krenning L, Koch A, van den Berg J, van den Broek B, Jalink K, Medema RH.
Nat Commun. 2016 Aug 26;7:12618. doi: 10.1038/ncomms12618.

The TRPM7 interactome defines a cytoskeletal complex linked to neuroblastoma progression.

Middelbeek J, Vrenken K, Visser D, Lasonder E, Koster J, Jalink K, Clark K, van Leeuwen FN.
Eur J Cell Biol. 2016 Jun 24. pii: S0171-9335(16)30111-X. doi: 10.1016/j.ejcb.2016.06.008.

Optimizing Imaging Conditions for Demanding Multi-Color Super Resolution Localization Microscopy.

Nahidiazar L, Agronskaia AV, Broertjes J, van den Broek B,Jalink K.
PLoS One. 2016 Jul 8;11(7):e0158884. doi: 10.1371/journal.pone.0158884. eCollection 2016

PFA fixation enables artifact-free super-resolution imaging of the actin cytoskeleton and associated proteins.

Leyton-Puig D, Kedziora KM, Isogai T, van den Broek B, Jalink K, Innocenti M.
Biol Open. 2016 Jul 15;5(7):1001-9. doi: 10.1242/bio.019570.

Cholesterol and ORP1L-mediated ER contact sites control autophagosome transport and fusion with the endocytic pathway.

Wijdeven RH, Janssen H, Nahidiazar L, Janssen L, Jalink K, Berlin I, Neefjes J.
Nat Commun. 2016 Jun 10;7:11808. doi: 10.1038/ncomms11808.

ATP Released by Injured Neurons Activates Schwann Cells.

Negro S, Bergamin E, Rodella U, Duregotti E, Scorzeto M, Jalink K, Montecucco C, Rigoni M.
Front Cell Neurosci. 2016 May 23;10:134. doi: 10.3389/fncel.2016.00134. eCollection 2016.

Optotaxis: Caged Lysophosphatidic Acid Enables Optical Control of a Chemotactic Gradient.

Hövelmann F, Kedziora KM, Nadler A, Müller R, Jalink K, Schultz C.
Cell Chem Biol. 2016 May 19;23(5):629-34. doi: 10.1016/j.chembiol.2015.11.019. Epub 2016 May 5.

Invadosomes – shaping actin networks to follow mechanical cues.

Kedziora KM, Isogai T, Jalink K, Innocenti M.
Front Biosci (Landmark Ed). 2016 Jun 1;21:1092-117.

Intracellular tortuosity underlies slow cAMP diffusion in adult ventricular myocytes.

Richards M, Lomas O, Jalink K, Ford KL, Vaughan-Jones RD, Lefkimmiatis K, Swietach P.
Cardiovasc Res. 2016 Jun 1;110(3):395-407. doi: 10.1093/cvr/cvw080. Epub 2016 Apr 18.

siFLIM: single-image frequency-domain FLIM provides fast and photon-efficient lifetime data. pdf-icon

Raspe M, Kedziora KM, van den Broek B, Zhao Q, de Jong S, Herz J, Mastop M, Goedhart J, Gadella TW, Young IT, Jalink K.
Nat Methods. 2016 Jun;13(6):501-4. doi: 10.1038/nmeth.3836. Epub 2016 Apr 18.

Rapid Remodeling of Invadosomes by Gi-coupled Receptors: DISSECTING THE ROLE OF Rho GTPases.

Kedziora KM, Leyton-Puig D, Argenzio E, Boumeester AJ, van Butselaar B, Yin T, Wu YI, van Leeuwen FN, Innocenti M, Jalink K, Moolenaar WH.
J Biol Chem. 2016 Feb 26;291(9):4323-33. doi: 10.1074/jbc.M115.695940. Epub 2016 Jan 6.

Beyond ion-conduction: Channel-dependent and -independent roles of TRP channels during development and tissue homeostasis.

Vrenken KS, Jalink K, van Leeuwen FN, Middelbeek J.
Biochim Biophys Acta. 2016 Jun;1863(6 Pt B):1436-46. doi: 10.1016/j.bbamcr.2015.11.008. Epub 2015 Nov 14. Review.

Genome-wide maps of nuclear lamina interactions in single human cells.

Kind J, Pagie L, de Vries SS, Nahidiazar L, Dey SS, Bienko M, Zhan Y, Lajoie B, de Graaf CA, Amendola M, Fudenberg G, Imakaev M, Mirny LA, Jalink K, Dekker J, van Oudenaarden A, van Steensel B.
Cell. 2015 Sep 24;163(1):134-47. doi: 10.1016/j.cell.2015.08.040. Epub 2015 Sep 10.

Initiation of lamellipodia and ruffles involves cooperation between mDia1 and the Arp2/3 complex.

Isogai T, van der Kammen R, Leyton-Puig D, Kedziora KM, Jalink K, Innocenti M.
J Cell Sci. 2015 Oct 15;128(20):3796-810. doi: 10.1242/jcs.176768. Epub 2015 Sep 8.

The molecular architecture of hemidesmosomes, as revealed with super-resolution microscopy.

Nahidiazar L, Kreft M, van den Broek B, Secades P, Manders EM, Sonnenberg A, Jalink K.
J Cell Sci. 2015 Oct 15;128(20):3714-9. doi: 10.1242/jcs.171892. Epub 2015 Sep 1.

Co-Orientation: Quantifying Simultaneous Co-Localization and Orientational Alignment of Filaments in Light Microscopy.

Nieuwenhuizen RP, Nahidiazar L, Manders EM, Jalink K, Stallinga S, Rieger B.
PLoS One. 2015 Jul 10;10(7):e0131756. doi: 10.1371/journal.pone.0131756. eCollection 2015.

MMP-2/9-Specific Activatable Lifetime Imaging Agent.

Rood MT, Raspe M, ten Hove JB, Jalink K, Velders AH, van Leeuwen FW.
Sensors (Basel). 2015 May 12;15(5):11076-91. doi: 10.3390/s150511076.

The rod domain is not essential for the function of plectin in maintaining tissue integrity.

Ketema M, Secades P, Kreft M, Nahidiazar L, Janssen H, Jalink K, de Pereda JM, Sonnenberg A.
Mol Biol Cell. 2015 Jul 1;26(13):2402-17. doi: 10.1091/mbc.E15-01-0043. Epub 2015 May 13.

Fourth-generation epac-based FRET sensors for cAMP feature exceptional brightness, photostability and dynamic range: characterization of dedicated sensors for FLIM, for ratiometry and with high affinity. pdf-icon

Klarenbeek J, Goedhart J, van Batenburg A, Groenewald D, Jalink K.
PLoS One. 2015 Apr 14;10(4):e0122513. doi: 10.1371/journal.pone.0122513. eCollection 2015.

REV7 counteracts DNA double-strand break resection and affects PARP inhibition.

Xu G, Chapman JR, Brandsma I, Yuan J, Mistrik M, Bouwman P, Bartkova J, Gogola E, Warmerdam D, Barazas M, Jaspers JE, Watanabe K, Pieterse M, Kersbergen A, Sol W, Celie PH, Schouten PC, van den Broek B, Salman A, Nieuwland M, de Rink I, de Ronde J, Jalink K, Boulton SJ, Chen J, van Gent DC, Bartek J, Jonkers J, Borst P, Rottenberg S.
Nature. 2015 May 28;521(7553):541-4. doi: 10.1038/nature14328. Epub 2015 Mar 23.

TRPM7 maintains progenitor-like features of neuroblastoma cells: implications for metastasis formation.

Middelbeek J, Visser D, Henneman L, Kamermans A, Kuipers AJ, Hoogerbrugge PM, Jalink K, van Leeuwen FN.
Oncotarget. 2015 Apr 20;6(11):8760-76.

Recording intracellular cAMP levels with EPAC-based FRET sensors by fluorescence lifetime imaging.

Raspe M, Klarenbeek J, Jalink K.
Methods Mol Biol. 2015;1294:13-24. doi: 10.1007/978-1-4939-2537-7_2.

Fluorescence resonance energy transfer microscopy (FRET).

Kedziora KM, Jalink K.
Methods Mol Biol. 2015;1251:67-82. doi: 10.1007/978-1-4939-2080-8_5.

CLIC4 regulates cell adhesion and β1 integrin trafficking.

Argenzio E, Margadant C, Leyton-Puig D, Janssen H, Jalink K, Sonnenberg A, Moolenaar WH.
J Cell Sci. 2014 Dec 15;127(Pt 24):5189-203. doi: 10.1242/jcs.150623. Epub 2014 Oct 24.

GqPCR-mediated signalling in the spotlight: from visualization towards dissection and quantification.

Jalink K, Adjobo-Hermans MJ.
Curr Pharm Biotechnol. 2014;15(10):893-915. Review.

Function and regulation of the channel-kinase TRPM7 in health and disease.

Visser D, Middelbeek J, van Leeuwen FN, Jalink K.
Eur J Cell Biol. 2014 Oct;93(10-12):455-65. doi: 10.1016/j.ejcb.2014.07.001. Epub 2014 Jul 8. Review.

An activatable, polarity dependent, dual-luminescent imaging agent with a long luminescence lifetime.

Rood MT, Oikonomou M, Buckle T, Raspe M, Urano Y, Jalink K, Velders AH, van Leeuwen FW.
Chem Commun (Camb). 2014 Sep 4;50(68):9733-6. doi: 10.1039/c4cc04015e.

Dopaminergic modulation of cAMP drives nonlinear plasticity across the Drosophila mushroom body lobes.

Boto T, Louis T, Jindachomthong K, Jalink K, Tomchik SM.
Curr Biol. 2014 Apr 14;24(8):822-31. doi: 10.1016/j.cub.2014.03.021. Epub 2014 Mar 27.

Astral microtubules control redistribution of dynein at the cell cortex to facilitate spindle positioning.

Tame MA, Raaijmakers JA, van den Broek B, Lindqvist A, Jalink K, Medema RH.
Cell Cycle. 2014;13(7):1162-70. doi: 10.4161/cc.28031. Epub 2014 Feb 10.

The fidelity of stochastic single-molecule super-resolution reconstructions critically depends upon robust background estimation.

Hoogendoorn E, Crosby KC, Leyton-Puig D, Breedijk RM, Jalink K, Gadella TW, Postma M.
Sci Rep. 2014 Jan 24;4:3854. doi: 10.1038/srep03854.

The NO/cGMP pathway inhibits transient cAMP signals through the activation of PDE2 in striatal neurons.

Polito M, Klarenbeek J, Jalink K, Paupardin-Tritsch D, Vincent P, Castro LR.
Front Cell Neurosci. 2013 Nov 18;7:211. doi: 10.3389/fncel.2013.00211. eCollection 2013.

TRPM7 triggers Ca2+ sparks and invadosome formation in neuroblastoma cells.

Visser D, Langeslag M, Kedziora KM, Klarenbeek J, Kamermans A, Horgen FD, Fleig A, van Leeuwen FN, Jalink K.
Cell Calcium. 2013 Dec;54(6):404-15. doi: 10.1016/j.ceca.2013.09.003. Epub 2013 Oct 16.

hiFRET: some tailwind for FRET resolves weak protein interactions.

Jalink K.
Nat Methods. 2013 Oct;10(10):947-8. doi: 10.1038/nmeth.2652. No abstract available.

WAPL-mediated removal of cohesin protects against segregation errors and aneuploidy.

Haarhuis JH, Elbatsh AM, van den Broek B, Camps D, Erkan H, Jalink K, Medema RH, Rowland BD.
Curr Biol. 2013 Oct 21;23(20):2071-7. doi: 10.1016/j.cub.2013.09.003. Epub 2013 Sep 19.

Detecting cAMP with an EPAC-based FRET sensor in single living cells.

Klarenbeek J, Jalink K.
Methods Mol Biol. 2014;1071:49-58. doi: 10.1007/978-1-62703-622-1_4.

An introduction to fluorescence imaging techniques geared towards biosensor applications.

Goedhart J, Hink MA, Jalink K.
Methods Mol Biol. 2014;1071:17-28. doi: 10.1007/978-1-62703-622-1_2. Review.

cAMP inhibits migration, ruffling and paxillin accumulation in focal adhesions of pancreatic ductal adenocarcinoma cells: effects of PKA and EPAC.

Burdyga A, Conant A, Haynes L, Zhang J, Jalink K, Sutton R, Neoptolemos J, Costello E, Tepikin A.
Biochim Biophys Acta. 2013 Dec;1833(12):2664-72. doi: 10.1016/j.bbamcr.2013.06.011. Epub 2013 Jun 22.

Induction of epithelial-mesenchymal transition (EMT) in breast cancer cells is calcium signal dependent.

Davis FM, Azimi I, Faville RA, Peters AA, Jalink K, Putney JW Jr, Goodhill GJ, Thompson EW, Roberts-Thomson SJ, Monteith GR.
Oncogene. 2014 May 1;33(18):2307-16. doi: 10.1038/onc.2013.187. Epub 2013 May 20.

Modulated electron-multiplied fluorescence lifetime imaging microscope: all-solid-state camera for fluorescence lifetime imaging.

Zhao Q, Schelen B, Schouten R, van den Oever R, Leenen R, van Kuijk H, Peters I, Polderdijk F, Bosiers J, Raspe M, Jalink K, Geert Sander de Jong J, van Geest B, Stoop K, Young IT.
J Biomed Opt. 2012 Dec;17(12):126020.

TRPM7 is required for breast tumor cell metastasis.

Middelbeek J, Kuipers AJ, Henneman L, Visser D, Eidhof I, van Horssen R, Wieringa B, Canisius SV, Zwart W, Wessels LF, Sweep FC, Bult P, Span PN, van Leeuwen FN, Jalink K.
Cancer Res. 2012 Aug 15;72(16):4250-61.

Phosphorylation of threonine 1736 in the C-terminal tail of integrin β4 contributes to hemidesmosome disassembly.

Frijns E, Kuikman I, Litjens S, Raspe M, Jalink K, Ports M, Wilhelmsen K, Sonnenberg A.
Mol Biol Cell. 2012 Apr;23(8):1475-85. doi: 10.1091/mbc.E11-11-0957. Epub 2012 Feb 22.

LPA is a chemorepellent for B16 melanoma cells: action through the cAMP-elevating LPA5 receptor.

Jongsma M, Matas-Rico E, Rzadkowski A, Jalink K, Moolenaar WH.
PLoS One. 2011;6(12):e29260. doi: 10.1371/journal.pone.0029260. Epub 2011 Dec 14.

Peptide-functionalized luminescent iridium complexes for lifetime imaging of CXCR4 expression.

Kuil J, Steunenberg P, Chin PT, Oldenburg J, Jalink K, Velders AH, van Leeuwen FW.
Chembiochem. 2011 Aug 16;12(12):1897-903. doi: 10.1002/cbic.201100271. Epub 2011 Jul 7.

A mTurquoise-based cAMP sensor for both FLIM and ratiometric read-out has improved dynamic range.

Klarenbeek JB, Goedhart J, Hink MA, Gadella TW, Jalink K.
PLoS One. 2011 Apr 29;6(4):e19170. doi: 10.1371/journal.pone.0019170.journal.

ATP changes the fluorescence lifetime of cyan fluorescent protein via an interaction with His148.

Borst JW, Willemse M, Slijkhuis R, van der Krogt G, Laptenok SP, Jalink K, Wieringa B, Fransen JA.
PLoS One. 2010 Nov 5;5(11):e13862. doi: 10.1371/journal.pone.0013862.

Spatial regulation of cyclic AMP-Epac1 signaling in cell adhesion by ERM proteins.

Gloerich M, Ponsioen B, Vliem MJ, Zhang Z, Zhao J, Kooistra MR, Price LS, Ritsma L, Zwartkruis FJ, Rehmann H, Jalink K, Bos JL.
Mol Cell Biol. 2010 Nov;30(22):5421-31. doi: 10.1128/MCB.00463-10. Epub 2010 Sep 20.

Nano-imaging of membrane topography affects interpretations in cell biology.

Jalink K, van Rheenen J.
Nat Methods. 2010 Jul;7(7):486. doi: 10.1038/nmeth0710-486. No abstract available.

Bright cyan fluorescent protein variants identified by fluorescence lifetime screening.

Goedhart J, van Weeren L, Hink MA, Vischer NO, Jalink K, Gadella TW Jr.
Nat Methods. 2010 Feb;7(2):137-9. doi: 10.1038/nmeth.1415. Epub 2010 Jan 17.

G protein-coupled receptors: the inside story.

Jalink K, Moolenaar WH.
Bioessays. 2010 Jan;32(1):13-6. doi: 10.1002/bies.200900153. Review.

Spatiotemporal regulation of chloride intracellular channel protein CLIC4 by RhoA.

Ponsioen B, van Zeijl L, Langeslag M, Berryman M, Littler D, Jalink K, Moolenaar WH.
Mol Biol Cell. 2009 Nov;20(22):4664-72. doi: 10.1091/mbc.E09-06-0529. Epub 2009 Sep 23.

Resistance to antiestrogen arzoxifene is mediated by overexpression of cyclin D1.

Zwart W, Rondaij M, Jalink K, Sharp ZD, Mancini MA, Neefjes J, Michalides R.
Mol Endocrinol. 2009 Sep;23(9):1335-45. doi: 10.1210/me.2008-0268. Epub 2009 May 28.

Parathyroid hormone activates TRPV5 via PKA-dependent phosphorylation.

de Groot T, Lee K, Langeslag M, Xi Q, Jalink K, Bindels RJ, Hoenderop JG.
J Am Soc Nephrol. 2009 Aug;20(8):1693-704. doi: 10.1681/ASN.2008080873. Epub 2009 May 7.

Direct spatial control of Epac1 by cyclic AMP.

Ponsioen B, Gloerich M, Ritsma L, Rehmann H, Bos JL, Jalink K.
Mol Cell Biol. 2009 May;29(10):2521-31. doi: 10.1128/MCB.01630-08. Epub 2009 Mar 9.

Immersion oil for high-resolution live-cell imaging at 37 degrees C: optical and physical characteristics.

Oomen LC, Sacher R, Brocks HH, Zwier JM, Brakenhoff GJ, Jalink K.
J Microsc. 2008 Nov;232(2):353-61. doi: 10.1111/j.1365-2818.2008.02106.x.

Quantitative image correction and calibration for confocal fluorescence microscopy using thin reference layers and SIPchart-based calibration procedures.

Zwier JM, Oomen L, Brocks L, Jalink K, Brakenhoff GJ.
J Microsc. 2008 Jul;231(Pt 1):59-69. doi: 10.1111/j.1365-2818.2008.02017.x.

8-pCPT-2′-O-Me-cAMP-AM: an improved Epac-selective cAMP analogue.

Vliem MJ, Ponsioen B, Schwede F, Pannekoek WJ, Riedl J, Kooistra MR, Jalink K, Genieser HG, Bos JL, Rehmann H.
Chembiochem. 2008 Sep 1;9(13):2052-4. doi: 10.1002/cbic.200800216. No abstract available.

A comparison of donor-acceptor pairs for genetically encoded FRET sensors: application to the Epac cAMP sensor as an example.pdf-icon

van der Krogt GN, Ogink J, Ponsioen B, Jalink K.
PLoS One. 2008 Apr 2;3(4):e1916. doi: 10.1371/journal.pone.0001916.

Spatiotemporal coupling of cAMP transporter to CFTR chloride channel function in the gut epithelia.

Li C, Krishnamurthy PC, Penmatsa H, Marrs KL, Wang XQ, Zaccolo M, Jalink K, Li M, Nelson DJ, Schuetz JD, Naren AP.
Cell. 2007 Nov 30;131(5):940-51.

Investigation into the mechanism regulating MRP localization.

van den Bout I, van Rheenen J, van Angelen AA, de Rooij J, Wilhelmsen K, Jalink K, Divecha N, Sonnenberg A.
Exp Cell Res. 2008 Jan 15;314(2):330-41. Epub 2007 Aug 29.

PKA-induced resistance to tamoxifen is associated with an altered orientation of ERalpha towards co-activator SRC-1.

Zwart W, Griekspoor A, Berno V, Lakeman K, Jalink K, Mancini M, Neefjes J, Michalides R.
EMBO J. 2007 Aug 8;26(15):3534-44. Epub 2007 Jul 12.

Regulation of connexin43 gap junctional communication by phosphatidylinositol 4,5-bisphosphate.

van Zeijl L, Ponsioen B, Giepmans BN, Ariaens A, Postma FR, Várnai P, Balla T, Divecha N, Jalink K, Moolenaar WH.
J Cell Biol. 2007 Jun 4;177(5):881-91. Epub 2007 May 29.

Intravital imaging of fluorescent markers and FRET probes by DNA tattooing.

Bins AD, van Rheenen J, Jalink K, Halstead JR, Divecha N, Spencer DM, Haanen JB, Schumacher TN.
BMC Biotechnol. 2007 Jan 3;7:2.

Direct measurement of cyclic AMP diffusion and signaling through connexin43 gap junctional channels.

Ponsioen B, van Zeijl L, Moolenaar WH, Jalink K.
Exp Cell Res. 2007 Jan 15;313(2):415-23. Epub 2006 Nov 6.

Activation of TRPM7 channels by phospholipase C-coupled receptor agonists.

Langeslag M, Clark K, Moolenaar WH, van Leeuwen FN, Jalink K.
J Biol Chem. 2007 Jan 5;282(1):232-9. Epub 2006 Nov 9.

A role for PtdIns(4,5)P2 and PIP5Kalpha in regulating stress-induced apoptosis.

Halstead JR, van Rheenen J, Snel MH, Meeuws S, Mohammed S, D’Santos CS, Heck AJ, Jalink K, Divecha N.
Curr Biol. 2006 Sep 19;16(18):1850-6.

Integrin cytoplasmic domain-associated protein-1 (ICAP-1) interacts with the ROCK-I kinase at the plasma membrane.

Stroeken PJ, Alvarez B, Van Rheenen J, Wijnands YM, Geerts D, Jalink K, Roos E.
J Cell Physiol. 2006 Sep;208(3):620-8.

Gold-enhanced biomolecular surface imaging of cells and tissue by SIMS and MALDI mass spectrometry.

Altelaar AF, Klinkert I, Jalink K, de Lange RP, Adan RA, Heeren RM, Piersma SR.
Anal Chem. 2006 Feb 1;78(3):734-42.

TRPM7, a novel regulator of actomyosin contractility and cell adhesion.

Clark K, Langeslag M, van Leeuwen B, Ran L, Ryazanov AG, Figdor CG, Moolenaar WH, Jalink K, van Leeuwen FN.
EMBO J. 2006 Jan 25;25(2):290-301. Epub 2006 Jan 12.

Spying on cGMP with FRET.

Jalink K.
Nat Methods. 2006 Jan;3(1):11-2. No abstract available.

An emerging role for PtdIns(4,5)P2-mediated signalling in human disease.

Halstead JR, Jalink K, Divecha N.
Trends Pharmacol Sci. 2005 Dec;26(12):654-60. Epub 2005 Oct 25. Review.

Characterization of sectioning fluorescence microscopy with thin uniform fluorescent layers: Sectioned Imaging Property or SIPcharts.

Brakenhoff GJ, Wurpel GW, Jalink K, Oomen L, Brocks L, Zwier JM.
J Microsc. 2005 Sep;219(Pt 3):122-32.

Integrins control motile strategy through a Rho-cofilin pathway.

Danen EH, van Rheenen J, Franken W, Huveneers S, Sonneveld P, Jalink K, Sonnenberg A.
J Cell Biol. 2005 May 9;169(3):515-26. Epub 2005 May 2. Erratum in: J Cell Biol. 2005 Aug 1;170(3):497.

PIP2 signaling in lipid domains: a critical re-evaluation.

van Rheenen J, Achame EM, Janssen H, Calafat J, Jalink K.
EMBO J. 2005 May 4;24(9):1664-73. Epub 2005 Apr 21.

Spatial separation of HLA-DM/HLA-DR interactions within MIIC and phagosome-induced immune escape.

Zwart W, Griekspoor A, Kuijl C, Marsman M, van Rheenen J, Janssen H, Calafat J, van Ham M, Janssen L, van Lith M, Jalink K, Neefjes J.
Immunity. 2005 Feb;22(2):221-33.

Detecting cAMP-induced Epac activation by fluorescence resonance energy transfer: Epac as a novel cAMP indicator.

Ponsioen B, Zhao J, Riedl J, Zwartkruis F, van der Krogt G, Zaccolo M, Moolenaar WH, Bos JL, Jalink K.
EMBO Rep. 2004 Dec;5(12):1176-80.

Tamoxifen resistance by a conformational arrest of the estrogen receptor alpha after PKA activation in breast cancer.

Michalides R, Griekspoor A, Balkenende A, Verwoerd D, Janssen L, Jalink K, Floore A, Velds A, van’t Veer L, Neefjes J.
Cancer Cell. 2004 Jun;5(6):597-605.

Correcting confocal acquisition to optimize imaging of fluorescence resonance energy transfer by sensitized emission.

van Rheenen J, Langeslag M, Jalink K.
Biophys J. 2004 Apr;86(4):2517-29.

The pleckstrin homology domain of phosphoinositide-specific phospholipase Cdelta4 is not a critical determinant of the membrane localization of the enzyme.

Lee SB, Várnai P, Balla A, Jalink K, Rhee SG, Balla T.
J Biol Chem. 2004 Jun 4;279(23):24362-71. Epub 2004 Mar 22

Calcium signaling regulates translocation and activation of Rac.

Price LS, Langeslag M, ten Klooster JP, Hordijk PL, Jalink K, Collard JG.
J Biol Chem. 2003 Oct 10;278(41):39413-21. Epub 2003 Jul 29.

Peptide diffusion, protection, and degradation in nuclear and cytoplasmic compartments before antigen presentation by MHC class I.

Reits E, Griekspoor A, Neijssen J, Groothuis T, Jalink K, van Veelen P, Janssen H, Calafat J, Drijfhout JW, Neefjes J.
Immunity. 2003 Jan;18(1):97-108.

Agonist-induced PIP(2) hydrolysis inhibits cortical actin dynamics: regulation at a global but not at a micrometer scale.

van Rheenen J, Jalink K.
Mol Biol Cell. 2002 Sep;13(9):3257-67.

Galpha(13) mediates activation of a depolarizing chloride current that accompanies RhoA activation in both neuronal and nonneuronal cells.

Postma FR, Jalink K, Hengeveld T, Offermanns S, Moolenaar WH.
Curr Biol. 2001 Jan 23;11(2):121-4.

Monitoring agonist-induced phospholipase C activation in live cells by fluorescence resonance energy transfer.

van der Wal J, Habets R, Várnai P, Balla T, Jalink K.
J Biol Chem. 2001 May 4;276(18):15337-44. Epub 2001 Jan 10.

High performance density gradient electrophoresis of subcellular organelles, protein complexes and proteins.

Tulp A, Verwoerd D, Benham A, Jalink K, Sier C, Neefjes J.
Electrophoresis. 1998 Jun;19(7):1171-8.

Synaptic defects and compensatory regulation of inositol metabolism in inositol polyphosphate 1-phosphatase mutants.

Acharya JK, Labarca P, Delgado R, Jalink K, Zuker CS.
Neuron. 1998 Jun;20(6):1219-29.

Exogenous phospholipase D generates lysophosphatidic acid and activates Ras, Rho and Ca2+ signaling pathways.

van Dijk MC, Postma F, Hilkmann H, Jalink K, van Blitterswijk WJ, Moolenaar WH.
Curr Biol. 1998 Mar 26;8(7):386-92.

Acute loss of cell-cell communication caused by G protein-coupled receptors: a critical role for c-Src.

Postma FR, Hengeveld T, Alblas J, Giepmans BN, Zondag GC, Jalink K, Moolenaar WH.
J Cell Biol. 1998 Mar 9;140(5):1199-209.

A G protein-coupled receptor phosphatase required for rhodopsin function.

Vinós J, Jalink K, Hardy RW, Britt SG, Zuker CS.
Science. 1997 Aug 1;277(5326):687-90.

InsP3 receptor is essential for growth and differentiation but not for vision in Drosophila.

Acharya JK, Jalink K, Hardy RW, Hartenstein V, Zuker CS.
Neuron. 1997 Jun;18(6):881-7.

The Drosophila light-activated conductance is composed of the two channels TRP and TRPL.

Niemeyer BA, Suzuki E, Scott K, Jalink K, Zuker CS.
Cell. 1996 May 31;85(5):651-9.

Sphingosine-1-phosphate rapidly induces Rho-dependent neurite retraction: action through a specific cell surface receptor.

Postma FR, Jalink K, Hengeveld T, Moolenaar WH.
EMBO J. 1996 May 15;15(10):2388-92.

Serum-induced membrane depolarization in quiescent fibroblasts: activation of a chloride conductance through the G protein-coupled LPA receptor.

Postma FR, Jalink K, Hengeveld T, Bot AG, Alblas J, de Jonge HR, Moolenaar WH.
EMBO J. 1996 Jan 2;15(1):63-72.

Lysophosphatidic acid-induced Ca2+ mobilization in human A431 cells: structure-activity analysis.

Jalink K, Hengeveld T, Mulder S, Postma FR, Simon MF, Chap H, van der Marel GA, van Boom JH, van Blitterswijk WJ, Moolenaar WH.
Biochem J. 1995 Apr 15;307 ( Pt 2):609-16.

Growth factor-like effects of lysophosphatidic acid, a novel lipid mediator.

Jalink K, Hordijk PL, Moolenaar WH.
Biochim Biophys Acta. 1994 Dec 30;1198(2-3):185-96. Review. No abstract available.

Inhibition of lysophosphatidate- and thrombin-induced neurite retraction and neuronal cell rounding by ADP ribosylation of the small GTP-binding protein Rho.

Jalink K, van Corven EJ, Hengeveld T, Morii N, Narumiya S, Moolenaar WH.
J Cell Biol. 1994 Aug;126(3):801-10.

Analysis of decaying unitary currents in on-cell patches of cells with a high membrane resistance.

Ravesloot JH, van Putten MJ, Jalink K, Ypey DL.
Am J Physiol. 1994 Mar;266(3 Pt 1):C853-69.

cAMP abrogates the p21ras-mitogen-activated protein kinase pathway in fibroblasts.

Hordijk PL, Verlaan I, Jalink K, van Corven EJ, Moolenaar WH.
J Biol Chem. 1994 Feb 4;269(5):3534-8.

The bioactive phospholipid lysophosphatidic acid is released from activated platelets.

Eichholtz T, Jalink K, Fahrenfort I, Moolenaar WH.
Biochem J. 1993 May 1;291 ( Pt 3):677-80.

Lysophosphatidic acid induces neuronal shape changes via a novel, receptor-mediated signaling pathway: similarity to thrombin action.

Jalink K, Eichholtz T, Postma FR, van Corven EJ, Moolenaar WH.
Cell Growth Differ. 1993 Apr;4(4):247-55.

Lysophosphatidic acid is a chemoattractant for Dictyostelium discoideum amoebae.

Jalink K, Moolenaar WH, Van Duijn B.

Proc Natl Acad Sci U S A. 1993 Mar 1;90(5):1857-61.

Thrombin receptor activation causes rapid neural cell rounding and neurite retraction independent of classic second messengers.

Jalink K, Moolenaar WH.
J Cell Biol. 1992 Jul;118(2):411-9.

Identification of a putative membrane receptor for the bioactive phospholipid, lysophosphatidic acid.

van der Bend RL, Brunner J, Jalink K, van Corven EJ, Moolenaar WH, van Blitterswijk WJ.

EMBO J. 1992 Jul;11(7):2495-501.

Mitogenic action of lysophosphatidic acid and phosphatidic acid on fibroblasts. Dependence on acyl-chain length and inhibition by suramin.

van Corven EJ, van Rijswijk A, Jalink K, van der Bend RL, van Blitterswijk WJ, Moolenaar WH.
Biochem J. 1992 Jan 1;281 ( Pt 1):163-9.

Lysophosphatidic acid: a bioactive phospholipid with growth factor-like properties.

Moolenaar WH, Jalink K, van Corven EJ.
Rev Physiol Biochem Pharmacol. 1992;119:47-65. Review. No abstract available.

Lysophosphatidic acid: a novel phospholipid with hormone- and growth factor-like activities.

Moolenaar WH, van der Bend RL, van Corven EJ, Jalink K, Eichholtz T, van Blitterswijk WJ.
Cold Spring Harb Symp Quant Biol. 1992;57:163-7. Review. No abstract available.

Lysophosphatidic acid, but not phosphatidic acid, is a potent Ca2(+)-mobilizing stimulus for fibroblasts. Evidence for an extracellular site of action.

Jalink K, van Corven EJ, Moolenaar WH.
J Biol Chem. 1990 Jul 25;265(21):12232-9.

Morphological and functional properties of rat dorsal root ganglion cells cultured in a chemically defined medium.

van Dorp R, Jalink K, Oudega M, Marani E, Ypey DL, Ravesloot JH.
Eur J Morphol. 1990;28(2-4):430-44.

Lysophosphatidate-induced cell proliferation: identification and dissection of signaling pathways mediated by G proteins.

van Corven EJ, Groenink A, Jalink K, Eichholtz T, Moolenaar WH.
Cell. 1989 Oct 6;59(1):45-54.

K+ conductance of mechanically dissociated rat sensory neurones in long term cultures in a defined medium.

Ypey DL, Jalink K, Ravesloot JH, Struwe P, van Dorp R, Oudega M, Marani E.
Pflugers Arch. 1989;414 Suppl 1:S129-30